The effect of angiotensin converting enzyme inhibitor captopril on proteinuria was evaluated in 10 patients with renal disease of different etilogy. Captopril (37.5 mg given daily in 3 divided doses) was administered for 8 weeks. In heavy proteinuria (more than 1 g/day) group (N = 5), 24 hours urinary protien decreased significantly on the 6th weeks after captopril treatment (from 7.0 ± 3.0 g to 1.6± 1.1 g, p < 0.05). But in low proteinuria (less than 1 g/day) group (N =5), the proteinuria decreasing effect of aptopril was not evident during the study period. Serum creatinine, lbumin, electrolytes, and blood pressure did not change significantly during the study period.
In conclusion, the proteinuria- decreasing rtfect of captopril is significantly good in heavy proteinuria patients but not evident in low proteinuria patients.
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